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Home - Products - GPCR/G Protein - Dopamine Receptor - Pramipexole dihydrochloride

Pramipexole dihydrochloride

CAS No. 104632-25-9

Pramipexole dihydrochloride( Mirapex | SND 19 )

Catalog No. M10227 CAS No. 104632-25-9

A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Pramipexole dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively.
  • Description
    A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively; also possesses low/insignificant affinity (500–10,000 nM) for the 5-HT1A, 5-HT1B, 5-HT1D, and α2-adrenergic receptors; used for treating Parkinson's disease (PD) and restless legs syndrome (RLS).Parkinson's Disease Approved.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Wistar rats weighing 250-300 g (16-18 weeks old)Dosage:0.25 mg/kg, 1 mg/kg Administration:Intraperitoneal injection, at 1 hour, 6 hours, 12 hours, 18 hours post-occlusionResult:Decreased infarction volume as compared to tMCAO (transient middle cerebral artery occlusion)-only animals.
  • Synonyms
    Mirapex | SND 19
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    Dopamine Receptor
  • Research Area
    Neurological Disease
  • Indication
    Parkinson Disease

Chemical Information

  • CAS Number
    104632-25-9
  • Formula Weight
    284.249
  • Molecular Formula
    C10H19Cl2N3S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    NC(S1)=NC2=C1C[C@@H](NCCC)CC2.Cl.Cl
  • Chemical Name
    2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, hydrochloride (1:2), (6S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Newman-Tancredi A, et al. J Pharmacol Exp Ther. 2002 Nov;303(2):805-14. 2. Kvernmo T, et al. Clin Ther. 2006 Aug;28(8):1065-78. 3. Millan MJ, et al. J Pharmacol Exp Ther. 2002 Nov;303(2):791-804.
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